Web23 Jan 2024 · Background Transferrin receptor 1 (TfR1), encoded by TFRC, is a key regulator of iron homeostasis and plays important roles in many diseases, including cancers. … Web17 Jan 2024 · Transferrin receptor (TFRC), which was overexpressed in cervical cancer and involved in the HIF-1 pathway, was associated with advanced clinical pathologic characteristics. It was also an...

TFRC Gene - GeneCards TFR1 Protein TFR1 Antibody

Web13 May 2024 · Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be downregulated via the iron regulatory protein and the iron-responsive element machinery to … WebTransferrin Receptor Protein-1 (TFRC) is a cell surface receptor that binds ferric-iron-loaded transferrin in the bloodstream at high affinity to facilitate iron uptake into cells. TFRC is therefore an integral component of the body’s iron supply chain and general homeostasis. biology and pathogenesis of chikungunya virus

Entry - *190010 - TRANSFERRIN RECEPTOR; TFRC - OMIM

Web6 Sep 2024 · The TFRC gene encodes the transferrin receptor, which is important for cellular iron uptake. Circulating apotransferrin (TF; 190000) binds 2 Fe (3+) ions to form holotransferrin, which binds to TFRC. The TFRC-holotransferrin complex is internalized by receptor-mediated endocytosis (summary by Jabara et al., 2016 ). WebFig. 1. The central biochemical event of ferroptotic cancer cell death. The central biochemical event of ferroptosis is involved in iron accumulation and lipid peroxidation, which leads to oxidative injury and cell death. ROS, reactive oxygen species. Iron is an important trace element in many species. Web27 Oct 2024 · Results presented Fig. 5c demonstrate that TFR1 (CD71) and iron regulatory protein 1 (IRP1) are downregulated in the presence of HSA-heme in Jurkat T cells, … dailymotion fuller house season 1 episode 1