WebApr 2, 2014 · Conclusion: Drug-induced liver injury from statins is rare and characterized by variable patterns of injury, a range of latencies to onset, autoimmune features in some cases, and persistent or chronic injury in 18% of patients, most of whom have an autoimmune phenotype. (H epatology 2014;60:679–686) Abbreviations AIH autoimmune … Websuch as methotrexate can lead to chronic hepatitis and cirrhosis, while others such as minocycline, nitrofurantoin and methyldopa are implicated in autoimmune hepatitis. Prolonged cholestasis and ductopenia resembling primary chronic biliary disease can occur. Drug-induced steato-hepatitis is also an uncommon pattern, but is well
Drug-Induced Liver Injury — Types and Phenotypes NEJM
WebJan 24, 2024 · Drug-induced autoimmune hepatitis It is a clinically challenging phenotype that has been described following exposure to certain medications (nitrofurantoin and minocycline) after a long latency period of up to 2 years (4). It has also been described with α- methyldopa, diclofenac, herbal supplements, infliximab, adalimumab and statins. WebSymptoms may include: Belly pain Tiredness and weakness Fever Nausea Vomiting Lack of appetite Dark urine Pale or clay-colored stools Yellowing of the skin and eyes (jaundice) react authentication jwt best practices
Statin-induced Liver Injury Patterns: A Clinical Review.
WebMar 23, 2005 · Statins are among the most widely prescribed medications in the western world. 1 Their benefit in the primary and secondary prevention of cardiovascular disease is unequivocal. The results from clinical trials have shown that statins decrease the mortality from coronary artery disease and decrease the incidence of myocardial infarction, … WebApr 11, 2024 · Statins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two … WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one … react authentication best practices