WebFeb 22, 2005 · The interaction of two polytopic membrane proteins, SREBP cleavage-activating protein (SCAP) and Insig, is a central event in the control of cholesterol … WebSterol regulatory element-binding protein signaling pathway regulates lipid and cholesterol homeostasis via transcriptional targeting of genes such as LDL receptor and HMG-CoA …
6.1: Cholesterol synthesis - Medicine LibreTexts
WebTargeted disruption of SCAP in the cholesterol-rich organs of mice caused organ dysgenesis, although these models do not exhibit absolute lethality. Brains contain the highest levels of cholesterol in the body, and SCAP deletion in astrocytes showed microcephaly, without effects on astrocyte survival [ 16 ]. WebJan 24, 2024 · Bei hoher Cholesterinkonzentration löst Cholesterin eine Konformationsänderung von SCAP aus, sodass es an das Insig-Protein bindet. Dadurch wird SREBP nicht zum Golgi-Apparat transportiert und die Transkription für Gene der Cholesterinsynthese nimmt ab. cedar bluff united methodist church
SREBP Cleavage Activating Protein - an overview - ScienceDirect
Web1 day ago · In the election season in Karnataka, 4 per cent Muslim quota row took a legal turn as the Supreme Court on Thursday agreed to list for hearing a plea challenging the Karnataka government's ... WebSep 1, 2002 · SCAP shares an intramembrane motif, called the sterol-sensing domain (SSD), with a few other integral membrane proteins that are also responsive to cholesterol. The working hypothesis is that a reduction in ER cholesterol depletes the SSD; this promotes the exit of “escort SCAP” from the ER, enabling it to transport its cargo, SREBP, to the ... WebNov 21, 2024 · Sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) is a cholesterol sensor that plays a critical role in regulating intracellular … cedar bluff town hall