WebNov 1, 2024 · The role of mitophagy receptors and adaptors including PINK1, Parkin, BNIP3, BNIP3L/NIX, and p62/SQSTM1, and the signaling pathways that govern mitophagy are impaired in cancer. Furthermore, ... which promotes the development of non-alcoholic fatty liver disease (NAFLD). Thus, Bnip3 plays an important role in mitochondrial dysfunction … WebDec 1, 2014 · PINK1 regulates the above via PI3-kinase/Akt and mitochondrial signalling. PINK1 is a potential target for therapeutics in certain cancers. Abstract. PTEN-induced …
The emerging multifaceted role of PINK1 in cancer biology
Webgression of benign liver adenoma to malignant HCC, several important questions remain to be answered. It is well known that PINK1 is cleaved and degraded in healthy mitochondria via the N-end rule pathway [16]. The levels of PINK1 are almost undetectable in most cells including cancer cells unless the mitochondria are depolarized. Therefore ... WebApr 3, 2024 · PINK1 did not accumulate into the VCM muscle (Fig. 4m,q ). NA treatment had no influence on muscle mitochondrial respiration and ATP content (Fig. 4j,k ), but it increased mtDNA amount (Fig. 4l... small was beautiful in this show
Retraction Note: Matrine promotes liver cancer cell ... - Springer
WebDec 14, 2024 · PINK1, human PTEN-induced kinase 1, accumulates when mitochondria are stimulated to cause damage and is then recruited downstream to selectively degrade abnormal mitochondria. Parkin is an E3 ubiquitinated ligase encoded by the PARK2 gene that mainly exists in the cytoplasm and can recognize damaged mitochondria [ 8, 9 ]. WebDec 12, 2024 · Here we show that activation of mGluR3 in breast cancer cells activates Rab27-dependent release of extracellular vesicles (EVs), which can transfer invasive … WebDec 1, 2015 · ALD is a chronic liver disease that is characterized by hepatic steatosis, hepatocyte cell death, inflammation, fibrosis and eventual liver cirrhosis and hepatocellular carcinoma. APAP-induced liver injury is characterized by massive central lobular hepatocyte necrosis. ... was not involved in the PINK1-dependent mitophagy of the cancer ... small warts on hands and fingers