WebPalmitoylation of Hh and Shh is also important for signaling. Mutation of the Shh N-terminal Cys to Ser results in a mutant Shh (Cys 25 → Ser) with reduced patterning activity in the … http://www.cvri.ucsf.edu/~chuang/pdf/gen186641.pdf

Palmitoylation of Hedgehog proteins by Hedgehog …

WebJun 23, 2010 · Background Sonic hedgehog (Shh) is a palmitoylated protein that plays key roles in mammalian development and human cancers. Palmitoylation of Shh is required … WebSince their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental … crown countertops reviews

Hhat is a palmitoylacyltransferase with specificity for N ...

WebHere, we have developed and exploited an in vitro Shh palmitoylation assay to purify Hhat to homogeneity. We provide direct biochemical evidence that Hhat is a PAT with specificity … WebJun 4, 2008 · Abstract. Palmitoylation of Sonic Hedgehog (Shh) is critical for effective long- and short-range signaling. Genetic screens uncovered a potential … WebPalmitoylation is the covalent attachment of fatty acids, such as palmitic acid, to cysteine ( S -palmitoylation) and less frequently to serine and threonine ( O -palmitoylation) residues … building companies albany wa