Mucin pathway

Author: lajs

August undefined, 2024

WebAbnormal gastro-oesophageal reflux and bile acids have been linked to the presence of Barrett's oesophageal premalignant lesion associated with an increase in mucin-producing goblet cells and MUC4 mucin gene overexpression. However, the molecular mechanisms underlying the regulation of MUC4 by bile acids are unknown. WebThe extracellular ligands and signal transduction pathways con-trolling mucin secretion have been studied for longer and in more depth than the exocytic machinery itself (30). The best-studied ligand is ATP that acts on the P2Y2 receptor to activate Gq and PLC-b1, resulting in generation of the second messengers IP3 and diacylglycerol (DAG).

UniProt

Web7 sept. 2024 · Association between Potential Etiologic Pathways and Total Mucin Concentrations in Sputum. Panel A shows total mucin concentration and smoking history. Data are for 69 participants who had never ... WebDistanţa Moieciu de Jos-Bucureşti în Km vă este reprezentată pe hartă. Traseu Moieciu de Jos-Bucureşti pe şosea. Distanţa rutieră dintre Moieciu de Jos şi Bucureşti, viteză, timp, … foss indoor outdoor carpet squares

Mucins and Wnt/β-catenin signaling in gastrointestinal …

WebGasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway Nat Cell Biol. 2024 Mar;24(3):364-372. doi: … Web1 apr. 2012 · The results suggest that cigarette smoke activates EGFR‐mediated signaling pathways, leading to Hif‐1α production and HIF‐1 activation, resulting in mucin expression in human airway epithelial cells. Cigarette smoking is strongly implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mucus hypersecretion is the key … WebDistanţa Mioveni-Bucureşti în Km vă este reprezentată pe hartă. Traseu Mioveni-Bucureşti pe şosea. Distanţa rutieră dintre Mioveni şi Bucureşti, viteză, timp, consum şi costul mediu. directv stream make a payment

IJMS Free Full-Text Analysis of Epithelial Growth Factor-Receptor ...

Regulated Mucin Secretion from Airway Epithelial Cells

Web3 aug. 2024 · Transmembrane mucins participate in various signalling pathways to promote carcinogenesis and pathogenesis, either via the extracellular domain or by directly interacting with receptors. 32, 46 MUC1-C, a powerful and representative mucin because of the presence of multiple phosphorylation sites, represents a hub protein of different … Web1 mar. 2016 · While many studies have shown the regulation of β-catenin by mucins, the Wnt/β-catenin pathway has also been shown to regulate mucin expression. In CRC, … directv stream network channelsWebRemarkably, loss of the mucin domain of Msb2 causes hyperactivity of the FG pathway, demonstrating an inhibitory role for mucin domains in MAPK pathway activation. Taken together, our data suggest that Msb2 is a signaling mucin that interacts with general components, such as Cdc42 and Sho1, to promote their function in the FG pathway. foss institute

"Web19 sept. 2024 · Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol . 2024 Mar;24:364-72. (IF=28.123) " - Mucin pathway

Mucin pathway

Gasdermin E mediates resistance of pancreatic adenocarcinoma to ...

WebTn, sialyl-Tn, and T are cell membrane-bound mucin-like carbohydrate structures that may be expressed in tumours due to blocked synthesis of the core carbohydrate chain of mucin-like structures. Their expression is strongly associated with prognosis in certain tumours, but the biological relationship between their expression and tumour ... Webvan der Sluis M, Schaart MW, de Koning B, Schierbeek H, Velcich A, Renes IB et al. Threonine metabolism in the intestine of mice: loss of mucin 2 induces the threonine catabolic pathway. Journal of Pediatric Gastroenterology and Nutrition . 2009;49:99-107. doi: 10.1097/MPG.0b013e3181a23dbe

Did you know?

Web5 mar. 2008 · The constitutive pathway continuously secretes sufficient mucin to maintain the mucus layer, whereas the regulated pathway affords a massive discharge as a … Web17 iul. 2024 · The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is …

WebAbstact. Pancreatic cancer is one of the most lethal cancers in the world, as it continues to be resistant to any therapeutic approaches. The high molecular weight glycoprotein mucin 4 (MUC4) is aberrantly expressed in pancreatic cancer and contributes to the regulation of differentiation, proliferation, metastasis, and the chemoresistance of pancreatic cancer cells. Web17 aug. 2024 · Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins have involved all of the procession of lung cancer, which is interacted with many receptor tyrosine kinases signal pathways and mediated cell …

Web22 iun. 2024 · To determine why there is more intracellular mucin proteins during resolution, we turned our attention to the autophagosome pathway as a means of controlling … Web30 mar. 2024 · KEGG PATHWAY is a collection of manually drawn pathway maps representing our knowledge of the molecular interaction, reaction and relation networks for: 1. Metabolism. Global/overview Carbohydrate Energy Lipid Nucleotide Amino acid Other amino Glycan. Cofactor/vitamin Terpenoid/PK Other secondary metabolite Xenobiotics …

WebThe transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of …

Web16 sept. 2024 · Several potential downstream pathways may link IL-1R1 signaling to mucin hypersecretion in CF. One candidate is SAM-pointed domain containing ETS transcription factor (SPDEF), a transcription factor (TF) that regulates mucous cell differentiation and mucin production in health and disease (22 – 24). A second candidate is endoplasmic … directv streaming no contractWeb13 mai 2009 · The signaling mucin Hkr1p functions redundantly with Msb2p in the HOG pathway (Tatebayashi et al., 2007), but its role in the FG pathway has not been examined. To determine whether Hkr1p functions in the FG pathway, the HKR1 gene was disrupted in a wild-type strain of the Σ1278b background and assessed for FG and MAPK activity. foss informaticaWeb23 apr. 2024 · Finally, we identified mucin glycosylation as a prominent pathway of SARS-CoV-2 host factor restriction . Mucins comprise a family of high-molecular weight, heavily O-glycosylated glycoproteins and are the primary constituent of mucus lining the epithelial tract of the lungs and gut (Lillehoj et al., 2013). directv stream now app download for laptop