Lysine succinylation

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August undefined, 2024

Web29 aug. 2013 · Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about … Web15 mar. 2024 · Lysine succinylation is a typical protein post-translational modification and plays a crucial role of regulation in the cellular process. Identifying succinylation sites is fundamental to explore its functions. Although many computational methods were developed to deal with this challenge, few considered semantic relationship between residues. We …

LncRNA GLTC targets LDHA for succinylation and enzymatic

Web29 aug. 2013 · Lysine succinylation was first shown to occur in the active site of homoserine trans-succinylase (Rosen et al., 2004), although this was assumed to … Web1 iun. 2024 · Lysine succinylation (Ksucc), defined as a transfer of a succinyl group to a lysine residue of a protein, is a newly identified protein post-translational modification … 2重積分範囲

SUCLA2 mutations cause global protein succinylation ... - Nature

Web17 ian. 2024 · Lysine succinylation (Ksu) exists in both eukaryotes and prokaryotes, and influences a variety of metabolism processes. However, little attention has been paid to … Web7 nov. 2024 · Protein lysine succinylation, mediated by succinyl-coenzyme A (succinyl-CoA), has been identified to play crucial roles in regulating a variety of cellular processes 3,4. WebSubsequently, we determined the succinylation site(s) on p53 through MS analysis. One succinylation site (lysine 120) in p53 was identified (Fig. 4G). Lysine 120 (K120) of p53 is evolutionary conserved across species (Fig. 4H). To further confirm this succinylated site in p53, we developed a specific antibody against succinylated K120 of p53 ... 2重積分領域

First comprehensive analysis of lysine succinylation in paper …

Global Analysis of Protein Lysine Succinylation Profiles and Their ...

WebHere we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified by … 2重積分解き方WebLysine succinylation (Ksucc) is a novel posttranslational modification that frequently occurs on chromatin proteins including histones and non-histone proteins. Histone Ksucc affects nucleosome dynamics by increasing the DNA unwrapping rate and accessibility. However, very little is known about the regulation and functions of Ksucc located on ... 2重管式熱交換器とは

"Web3 iun. 2024 · Background: Lysine succinylation, an important protein posttranslational modification (PTM), is widespread and conservative. The regulatory functions of succinylation in leaf color has been reported. " - Lysine succinylation

Lysine succinylation

Web23 nov. 2024 · a Quantitation of murine liver proteome succinylation shows TCA cycle enzymes are targets of lysine succinylation in mice (C57/BL6, n = 10 wild-type, n = 10 Sirt5 −/−).The SCL complex shows ... WebSuccinylation involves the transfer of a succinyl group to a protein molecule at its lysine (K) residue.107 Succinylation plays an important role in the growth and development of …

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Web21 sept. 2024 · Protein lysine succinylation (Ksucc) represents an important regulatory mechanism of tumor development. In this work, the difference of protein Ksucc between HCMEC/D3 co-cultured with U87 (glioma ... WebLysine succinylation is a posttranslational modification regulated by SIRT5. •. We profile lysine succinylation in mammalian fibroblasts and liver tissue. •. Succinylation is present on diverse mitochondrial and nonmitochondrial proteins. •. SIRT5 suppresses pyruvate dehydrogenase complex and succinate dehydrogenase.

Web28 aug. 2024 · Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored. Proteomic quantification of lysine succinylation was performed in human GC tissues and adjacent normal tissues by mass spectrometry. The mRNA and protein … WebLysine succinylation is a new posttranslational modification identified in histone proteins of Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa. However, very little is known about their scope and cellular distribution. Here, using LC–MS/MS to identify parasite peptides enriched by immunopurification with succinyl lysine antibody, …

Web14 apr. 2024 · Yang et al. described a novel role for HAT1 in HepG2 cell lines, in which HAT1 functions as the lysine-succinyl transferase of histone and nonhistone proteins. In HAT1-depleted cells, the succinylation level of 324 sites in 204 proteins is inhibited, and these proteins are widely localized and participate in multiple cellular pathways. Web15 sept. 2015 · Protein lysine acylation, including acetylation and succinylation, has been found to be a major post-translational modification (PTM) and is associated with the …

WebLncRNA GLTC targets LDHA for succinylation and enzymatic activity to promote progression and radioiodine resistance in papillary thyroid cancer Cell Death Differ. 2024 Apr 8. ... promotes the succinylation of LDHA at lysine 155 (K155) via competitive inhibition of the interaction between SIRT5 and LDHA, thereby promoting LDHA …

Web1 sept. 2015 · The expanding landscape of protein acylation coupled with the important role of the corresponding acyl-CoAs and the sirtuins in metabolic regulation have led to the idea that these new acyl-based lysine modifications are important regulators of metabolism (Fig. 3).Indeed, proteomic studies on lysine malonylation, succinylation, and glutarylation … 2釐米Web21 sept. 2024 · Protein lysine succinylation (Ksucc) represents an important regulatory mechanism of tumor development. In this work, the difference of protein Ksucc between … 2釐米是幾公分Web11 nov. 2024 · Lysine succinylation is a novel, broad-spectrum, dynamic, non-enzymatic protein post-translational modification (PTM). Succinylation is essential for the … 2重積分型ad変換器